VINTUM 4.5

Win Tough Infections…

VINTUM 4.5 gm
Piperacillin 4gm & Tazobactam 500 mg (IV) Injection

Tagline:
Broad-Spectrum Defense Against Complex Infections

Key Features:

• Piperacillin: Acts by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting cell wall synthesis, which is essential for bacterial growth and replication.
• Tazobactam: A potent extended-spectrum beta-lactamase inhibitor that protects Piperacillin from degradation by beta-lactamase enzymes, extending its spectrum of activity against resistant bacteria.
• Comprehensive Coverage: Piperacillin/Tazobactam is highly effective against a wide range of bacteria, making it the drug of choice for the treatment of complicated skin and soft tissue infections (cSSTIs).

Indication:
Vintum 4.5 gm is indicated for the treatment of a variety of severe bacterial infections, particularly those caused by resistant organisms, including:

• Complicated Intra-abdominal Infections: Including peritonitis and abscesses.
• Peritonitis: Inflammation of the peritoneum, often due to infection.
• Appendicitis: Infection and inflammation of the appendix.
• Diabetic Foot Ulcer: Infections associated with diabetic foot wounds.
• Ventilator-Associated Pneumonia (VAP): Pneumonia that occurs in patients receiving mechanical ventilation.
• Febrile Neutropenia: Treatment of infections in patients with low neutrophil counts, often due to chemotherapy.
• Nosocomial Pneumonia: Hospital-acquired pneumonia, including infections caused by resistant bacteria.
• Burns: Infections associated with burn wounds.
• Abscess: Localized collections of pus due to infection.
• Sepsis: Life-threatening infections that spread throughout the body.
• Complicated Urinary Tract Infections (cUTIs): UTIs that are difficult to treat due to resistance or underlying conditions.

Mode of Action:

• Piperacillin: Inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This action prevents the cross-linking of peptidoglycan chains, which are necessary for bacterial cell wall strength and rigidity, leading to bacterial cell lysis and death.
• Tazobactam: Extends the antibacterial activity of Piperacillin by inhibiting beta-lactamase enzymes that would otherwise degrade Piperacillin. This combination ensures a broader spectrum of activity, particularly against beta-lactamase-producing bacteria.

How to Take Vintum 4.5 gm:

• Administration: Vintum 4.5 gm is administered as an intravenous (IV) infusion. The preparation and administration should be carried out by a healthcare professional in a clinical setting.
• Dosage Frequency: The standard dosage is 4.5 gm every 8 hours. The exact duration and frequency of treatment depend on the severity of the infection and the patient’s response.
• Reconstitution: The injection should be reconstituted with the appropriate diluent before administration, following the manufacturer’s instructions or healthcare provider’s guidance.

Dosage:

• Standard Dosage: 4.5 gm of Piperacillin/Tazobactam administered every 8 hours via intravenous infusion. The duration of treatment depends on the type and severity of the infection.

Possible Side Effects:
While Vintum 4.5 gm is generally well-tolerated, some patients may experience side effects. Common side effects include:

• Gastrointestinal Issues: Diarrhea, nausea, vomiting, or abdominal pain.
• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Headache: Some patients may experience mild to moderate headaches.
• Allergic Reactions: Rash, itching, or hives. Severe allergic reactions (anaphylaxis) are rare but require immediate medical attention.
• Hematologic Changes: Rarely, Piperacillin/Tazobactam may cause changes in blood counts, such as leukopenia, thrombocytopenia, or anemia. Regular monitoring may be required during prolonged therapy.
• Electrolyte Imbalance: Monitor for potential imbalances, particularly in patients receiving long-term therapy.
• Superinfection: Prolonged use of antibiotics can sometimes lead to the overgrowth of non-susceptible organisms, such as fungi.

Precautions:

• Renal Function: Use with caution in patients with renal impairment. Dose adjustments may be necessary, and regular monitoring of renal function is recommended.
• Liver Function: Regular monitoring may be necessary in patients with pre-existing liver conditions.
• Bleeding Risk: Piperacillin may increase the risk of bleeding. Monitor patients for signs of bleeding, especially those on anticoagulants.
• Drug Interactions: Inform your healthcare provider of all medications you are taking, as Piperacillin/Tazobactam can interact with certain drugs, potentially affecting their efficacy.

Consult Your Doctor:

• Before starting Vintum 4.5 gm if you have any known allergies, particularly to penicillins, cephalosporins, or beta-lactamase inhibitors, or if you have kidney or liver disease.
• If you experience any severe or unusual symptoms, particularly signs of an allergic reaction, gastrointestinal distress, or bleeding.

For guidance on managing your condition and to discuss any concerns regarding your treatment plan.