NOXVIN 40 / NOXVIN 60

Noxvin 40/60
Enoxaparin Sodium 40mg / 60mg Injection (PFS)

Tagline:
Reliable Protection Against Clots: Safe, Effective, and Trusted Anticoagulation

Key Features:

• Anti-Xa Factor Action: Noxvin offers potent anti-Xa factor activity, effectively inhibiting the blood clotting mechanism.
• Anticoagulant Effect: Enoxaparin binds to and potentiates the action of antithrombin III, a serine protease inhibitor, leading to the inhibition of thrombin and factor Xa, thus preventing the formation of clots.
• Clinical Efficacy: Enoxaparin 40 mg/day has been shown to significantly reduce the frequency of venous thromboembolism (VTE) in nonsurgical patients at increased risk for deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Safety in Pregnancy: Enoxaparin is safe for use during pregnancy, offering effective prophylaxis against gestational VTE and reducing the risk of pregnancy loss in women with thrombophilia.

Indication:
Noxvin 40/60 is indicated for the prevention and treatment of various thromboembolic disorders, including:

• Venous Thromboembolism (VTE): Prophylaxis and treatment of DVT and PE, particularly in patients at high risk.
• Thrombophilia: Prevention of thromboembolic events in individuals with inherited or acquired thrombophilia.
• Preeclampsia: Management of preeclampsia in pregnancy, reducing the risk of complications associated with abnormal clotting.
• Miscarriage: Prevention of recurrent miscarriage in women with thrombophilia or other clotting disorders.
• Postpartum Thrombo Prophylaxis: Prevention of thromboembolic events in the postpartum period, particularly in women with a history of VTE or other risk factors.
• Cerebral Thromboembolism: Treatment and prevention of thromboembolic events in the brain, including stroke and transient ischemic attacks (TIAs).

Mode of Action:
Enoxaparin, the active ingredient in Noxvin, is a low molecular weight heparin (LMWH) that exerts its anticoagulant effects by inhibiting factor Xa and to a lesser extent, thrombin. By binding to antithrombin III, Enoxaparin accelerates the inactivation of factor Xa and reduces the formation of thrombin, effectively preventing the formation and propagation of blood clots.

How to Take Noxvin 40/60:

• Administration: Noxvin is administered as a subcutaneous (SC) injection. It comes in a pre-filled syringe (PFS) for easy and accurate dosing.
• Dosage Frequency: The standard dosage is once daily, although the exact dose and frequency may vary depending on the indication and patient-specific factors.
• Injection Technique: The injection is typically administered in the abdominal area, avoiding the navel and waistline. Rotate injection sites to minimize local irritation.

Dosage:

• Standard Dosage:
• Noxvin 40mg: Typically used for prophylaxis of VTE in moderate-risk patients or in pregnancy.
• Noxvin 60mg: Often used in higher-risk patients or for treatment purposes, as determined by a healthcare provider.

Possible Side Effects:
While Noxvin is generally well-tolerated, some patients may experience side effects. Common side effects include:

• Injection Site Reactions: Pain, bruising, or redness at the injection site.
• Bleeding: As an anticoagulant, Enoxaparin can increase the risk of bleeding. Signs of bleeding include unusual bruising, blood in urine or stools, nosebleeds, or prolonged bleeding from cuts.
• Thrombocytopenia: Rarely, Enoxaparin can cause a decrease in platelet count (thrombocytopenia), which may increase bleeding risk. Regular monitoring of platelet counts is recommended.
• Allergic Reactions: Rash, itching, or hives. Severe allergic reactions (anaphylaxis) are rare but require immediate medical attention.
• Osteoporosis: Long-term use of Enoxaparin may be associated with an increased risk of osteoporosis.

Precautions:

• Bleeding Risk: Use with caution in patients with a history of bleeding disorders, peptic ulcers, or other conditions that may increase bleeding risk.
• Renal Impairment: Enoxaparin is primarily excreted by the kidneys, so dose adjustments may be necessary in patients with renal impairment.
• Pregnancy and Lactation: Enoxaparin is safe for use during pregnancy but should be used under the supervision of a healthcare provider. It is also considered safe during breastfeeding.
• Drug Interactions: Inform your healthcare provider of all medications you are taking, especially other anticoagulants, antiplatelet agents, or NSAIDs, as these can increase the risk of bleeding.

Consult Your Doctor:

• Before starting Noxvin if you have any known allergies, particularly to heparins or other anticoagulants, or if you have a history of bleeding disorders.
• If you experience any signs of excessive bleeding, thrombocytopenia, or allergic reactions.
• For guidance on managing your condition and to discuss any concerns regarding your treatment plan.

Disclaimer: This information is for general knowledge only and should not be considered medical advice. Always consult with a healthcare professional for personalized guidance.