Cefoperazone & Sulbactam (I.V/I.M) Injection 

Cefoperazone and Sulbactam: A Powerful Combination

Cefoperazone is a third-generation cephalosporin antibiotic, and sulbactam is a beta-lactamase inhibitor. When combined, they form a potent antibiotic combination that is effective against a wide range of gram-negative bacteria, including those that are resistant to other antibiotics. 

Advantages of Cefoperazone and Sulbactam

• Broad Spectrum: Effective against both gram-positive and gram-negative bacteria.
• Resistant Strains: Can be used to treat infections caused by resistant strains, such as extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.
• Cost-Effective: Often considered a cheaper alternative to meropenem, especially in countries with limited healthcare resources.
• Synergistic Effect: The combination of cefoperazone and sulbactam enhances the antibiotic’s activity and helps to overcome bacterial resistance. 

Indications for Cefoperazone and Sulbactam

• Respiratory Tract Infections: Pneumonia, bronchitis
• Intra-Abdominal Infections: Peritonitis, abscesses
• Urinary Tract Infections: Cystitis, pyelonephritis
• Skin and Soft Tissue Infections: Cellulitis, abscesses
• Septicemia: Bloodstream infections
• Gynecological Infections: Pelvic inflammatory disease, endometritis
• Meningitis: Inflammation of the meninges (the protective membranes surrounding the brain and spinal cord)
• Bone and Joint Infections: Osteomyelitis, arthritis
• Infections in Neutropenic Patients: Patients with low white blood cell counts

Dosage

The dosage of cefoperazone and sulbactam varies depending on the severity of the infection, the patient’s weight, and renal function. Consult a healthcare professional for specific dosing instructions. 

General dosage guidelines:

• Adults: 2-4 grams per day in divided doses.

Precautions

• Hypersensitivity: Do not use if allergic to cephalosporins or penicillins.
• Renal Impairment: Dosage adjustment may be necessary in patients with kidney problems.
• Bleeding: May increase the risk of bleeding in patients taking certain medications (e.g., anticoagulants).
• Superinfection: Can lead to overgrowth of resistant bacteria.

Disclaimer: This information is for general knowledge only and should not be considered medical advice. Always consult with a healthcare professional for personalized guidance.