Sitagliptin 50 mg & Metformin Prolonged Release 500 mg Tablets

Pack: 10 tablets/strip

Dosage:

• Recommended Dose: One tablet twice daily, typically taken with meals to reduce the risk of gastrointestinal side effects.
• Special Populations:
  • Renal Impairment: Dose adjustments may be necessary based on kidney function. Consult with a healthcare professional.
  • Hepatic Impairment: Use with caution; liver function should be monitored.
  • Elderly: Dose adjustments are generally not required, but monitoring of kidney function is advised.

Mode of Action:

• Sitagliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin levels, which helps regulate blood glucose by enhancing insulin release and decreasing glucagon levels in a glucose-dependent manner.
• Metformin Prolonged Release: A biguanide that reduces hepatic glucose production and improves insulin sensitivity, leading to better glycemic control. The prolonged-release formulation allows for steady absorption and reduces the incidence of gastrointestinal side effects.

Indication:

• Management of Type 2 diabetes mellitus in adults, particularly in patients who require a combination of sitagliptin and metformin for improved glycemic control.

How to Take Lasita M50:

• Take one tablet twice daily, with meals to minimize gastrointestinal side effects such as nausea and diarrhea.
• Swallow the tablet whole with water. Do not crush or chew the tablet, as it is designed for prolonged release.
• Maintain a consistent routine for taking the medication to ensure optimal blood glucose control.

Possible Side Effects:
As with any medication, Lasita M50 may cause side effects, although not everyone will experience them. Common side effects include:

• Gastrointestinal Issues: Nausea, diarrhea, stomach pain, or indigestion, particularly when first starting the medication.
• Hypoglycemia (Low Blood Sugar): More likely if combined with other antidiabetic medications. Symptoms may include dizziness, sweating, confusion, and shaking.
• Upper Respiratory Tract Infections: Symptoms may include a sore throat, runny nose, or cough.
• Headache: A common side effect that may decrease over time.
• Joint Pain: Some patients may experience joint pain, which should be reported to a healthcare provider if severe.
• Vitamin B12 Deficiency: Long-term use of metformin can lead to vitamin B12 deficiency, potentially causing anemia or neuropathy.
• Pancreatitis: Rare but serious, symptoms include severe abdominal pain, nausea, and vomiting.

Precautions:

• Renal Function: Regular monitoring is required, especially in patients with pre-existing kidney conditions.
• Liver Function: Use with caution and monitor liver enzymes periodically.
• Pancreatitis Risk: Be aware of the symptoms and seek immediate medical attention if they occur.
• Lactic Acidosis: Although rare, metformin can cause lactic acidosis, a serious condition that requires immediate medical attention. Symptoms include rapid breathing, muscle pain, and severe weakness.
• Allergic Reactions: Rarely, severe allergic reactions may occur. Seek medical attention if symptoms such as rash, itching, or swelling occur.

Consult Your Doctor:

• Before starting Lasita M50 if you have any underlying medical conditions, particularly those affecting the kidneys, liver, or pancreas.
• If you experience any unusual symptoms or side effects, especially signs of hypoglycemia or lactic acidosis.
• For personalized advice on managing diabetes, including diet, exercise, and other lifestyle modifications.

Disclaimer:
This information is provided for educational purposes only. For personalized medical advice and treatment options, consult a healthcare professional.